Professor Eric Reynolds AO
CONTACT
E-mail: e.reynolds@unimelb.edu.au
Telephone: +61 3 9341 1547
QUALIFICATIONS
- Bachelor of Science (University of Melbourne 18-Aug-1973)
- Doctor of Philosophy (University of Melbourne 29-Jul-1978)
POSITION
- Head, Melbourne Dental School
- CEO, Oral Health CRC
- Associate Dean, Faculty of Medicine, Dentistry and Health Sciences
SHORT HISTORY
Professor EC Reynolds has over 20 years experience in molecular biology, biochemistry, immunology, microbiology, cariology and periodontology. He has published over 172 peer-reviewed publications and 19 patents and has supervised over 50 BSc(Hons), BDentStud, MDSc and PhD students. Seven patents have been licensed to Recaldent Pty Ltd and GC (Japan) and another six have been licensed to CSL Ltd. Professor Reynolds has been closely involved in technology transfer associated with all licence agreements.
In 1999 Professor Reynolds was invited to join the Editorial Board of the Journal of Dental Research; the pre-eminent dental journal of the International Association for Dental Research (IADR) and the American Association for Dental Research (AADR).
Selected awards:
- William J. Gies Award presented by the IADR and the AADR for the best paper published in the Journal of Dental Research in 1992
- Supervisor of Hatton award recipient, IADR meeting (1995, 1997,1998, 2000,2006, 2007)
- Alan Docking Science Award presented by the IADR ANZ Division for outstanding scientific achievement in the field of dental research 1997
- Dairy Industry Association of Australia – The Loftus Hill Memorial Medal Award of Merit for outstanding scientific achievement 2001
- Clunies Ross National Science and Technology Award to recognize outstanding achievement in the successful application of science and technology 2002
- The Victoria Prize for technological innovation which has significantly advanced the State of Victoria’s knowledge base (2005)
- Anne and Eric Smorgon Memorial Award for outstanding contribution to science, technology and/or engineering (2005)
- Officer of the Order of Australia (AO) for service to community dental health through research and development of preventive and restorative products, to dental education through curriculum development, and as an administrator and teacher (2005)
- Elected Honorary Fellow of the International College of Dentists (2008)
- Elected Fellow of the Aust Academy of Technological Sciences and Engineering (2008)
- 181 invited keynote speaker presentations between 1998 – 2009 at major meetings worldwide
- Past and Current Representation on Major Scientific Bodies
- NH&MRC Discipline Panels, (i) Surgery, Dentistry and Radiology, (ii) Microbiology, (iii) Development Grant
- Member, Editorial Board, Australian Dental Journal
- Member, Research Advisory Committee, Australian Dental Research Foundation Inc
- IADR Dental Research Hatton Award Committee
- IADR GSK Innovation in Oral Care Expert Review Panel
- Editorial Board, Journal of Dental Research
- Past President, IADR, Australian and New Zealand Division.
top of pageRESEARCH INTERESTS
- Molecular processes characterizing the pathology and repair of dental caries and the pathology, prevention and treatment of periodontal diseases.
MEMBERSHIPS
- International Association for Dental Research
- American Society for Microbiology
- American Society for Biochemistry and Molecular Biology
- Australian Dental Association
CURRENT PUBLICATIONS (Last 5 years)
Publications in 2009
Book Chapters
- Additional aids to the remineralisation of tooth structure. 2009 in Preservation and Restoration of Tooth Structure. Knowledge Books & Software(Varsity Lakes, QLD) Authors(s): E REYNOLDS, Walsh
Journal Articles
- Response of Porphyromonas gingivalis to Heme Limitation in Continuous Culture. Journal of Bacteriology 191 (3); 1044-1055, 2009. S DASHPER, C ANG, P VEITH, H L MITCHELL, W H A LO, C SEERS, K WALSH, N SLAKESKI, D CHEN, J LISSEL, C BUTLER, N O'BRIEN-SIMPSON, I Barr, E REYNOLDS
- The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis Inactivate the Th2 cytokines interleukin-4 and interleukin-5. Infection and Immunity 77 (4), 1451-1458; 2009. V TAM, N O'BRIEN-SIMPSON, Y CHEN, SCJ Sanderson, BK Kinnear, E REYNOLDS.
Publications in 2008
Book Chapters
- Applied genomics of some oral bacteria. 2008 in Molecular Oral Microbiology. Caister Academic Press(Norwich). S DASHPER, P VEITH, C S ANG, P S Zilm, E REYNOLDS.
Journal Articles
- Application of 16O/18O reverse proteolytic labelling to determine the effect of biofilm culture on the cell envelope proteome of Porphyromonas gingivalis W50. Proteomics 8, 1645-1660; 2008. C ANG, P VEITH, S DASHPER, E REYNOLDS
- Calcium phosphate-based remineralization systems: scientific evidence? Australian Dental Journal 53, 268-273; 2008. E REYNOLDS
- Remineralization of enamel subsurface lesions in situ by the use of three commercially available sugar-free gums. International Journal of Paediatric Dentistry 18, 284-290; 2008. D MANTON, G WALKER, F CAI, N COCHRANE, P SHEN, E REYNOLDS
- Characterizatin of T Cell Responses to the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis in BALB/c Mice1. Journal of Immunology 181 (6) 4150-4158; 2008. V TAM, N O'BRIEN-SIMPSON, R PATHIRANA, L FRAZER, E REYNOLDS
- Comparative analysis of three commercial saliva testing kits with a standard saliva buffering test. Australian Dental Journal 53, 140-144; 2008. Y KITASAKO, M BURROW, M STACEY, N HUQ, E REYNOLDS, J TAGAMI
- Effect of ozone and Tooth Mousse on the efficacy of Carbamide Peroxide Bleaching. Australian Dental Journal Volume: 53 (2) 128-132; 2008. D MANTON, R BHIDE, M HOPCRAFT, E REYNOLDS
- Enamel Subsurface Lesion Remineralisation with Casein Phosphopeptide Stabilised Solutions of Calcium, Phosphate and Fluoride. Caries Research 42, 88-97; 2008.N COCHRANE, S SARANATHAN, F CAI, K CROSS, E REYNOLDS
- Flouride and casein phosphopeptide-amorphous calcium phosphate. Journal of Dental Research 87 (4) 344-348; 2008. E REYNOLDS, F CAI, N J COCHRANE, P SHEN, G WALKER, M MORGAN, C REYNOLDS
- Remineralizatin of enamel subsurface lesions in situ by the use of three commercially available sugar-free gums. International Journal of Paediatric Dentistry 18, 284-290; 2008. D J MANTON, G WALKER, F CAI, N J COCHRANE, P SHEN, E REYNOLDS
- The anticariogenic effect of sugar-free gum containing CPP-ACP nanocomplexes on approximal caries determined using digital bitewing radiography. Caries Research 42, 171-184; 2008. M MORGAN, G ADAMS, D BAILEY, C TSAO, S FISCHMAN, E REYNOLDS
- The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts. Microbiology 154, 2904-2911; 2008. R D PATHIRANA, N O'BRIEN-SIMPSON, K VISVANATHAN, J HAMILTON, E REYNOLDS
Publications in 2007
Journal Articles
- A Review of the Salivary Proteome and Peptidome and Saliva-derived Peptide Therapeutics. International Journal of Peptide Research and Therapeutics 13, 547-564; 2007. N HUQ, K CROSS, M UNG, H MYROFORIDIS, P VEITH, D CHEN, D STANTON, H HE, B WARD, E REYNOLDS
- A prospective clinical study of non-submerged immediate implants: clinical outcomes and esthetic results. Clinical Oral Implants Research 18 (5) 552-562; 2007. S CHEN, I DARBY, E REYNOLDS
- Antimicrobial Peptides and their Potential as Oral Therapeutic Agents. International Journal of Peptide Research and Therapeutics 13 (4) 505-516; 2007. S DASHPER, S LIU, E REYNOLDS
- Casein Phosphopeptides in Oral Health - chemistry and Clinical applications. Current Pharmaceutical Design 13 (8) 793-800; 2007. K CROSS, N HUQ, E REYNOLDS
- Effect of addition of citric acid and casein phosphopeptide-amorphous calcium phosphate to a sugar-free chewing gum on enamel remineralization in situ. Caries Research 41(5) 377-383; 2007. F CAI, D MANTON, P SHEN, G WALKER, K CROSS, Y YUAN, C REYNOLDS, E REYNOLDS
- Effects of various forms of calcium added to chewing gum on initial enamel carious lesions in situ. Caries Research 41 (5) 336; 2007. E REYNOLDS, J Vincent
- Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells. Infection and Immunity 75 (5) 2484-2492; 2007. R D PATHIRANA, N O'BRIEN-SIMPSON, K VISVANATHAN, J HAMILTON, E REYNOLDS
- Kgp and RgpB, but Not RgpA, Are Important for Porphyromonas gingivalis Virulence in the Murine Periodontitis Model. Infection and Immunity 75 (3) 1436-1442; 2007. R D PATHIRANA, N O'BRIEN-SIMPSON, G BRAMMAR, N SLAKESKI, E REYNOLDS
- Long in the Tooth: Oral Bacterial Communities and chronic Periodontitis. Microbiology Australia 28 (3) 113-115; 2007. S DASHPER, S BYRNE, R K ORTH, E REYNOLDS
- Prevention of demineralization around orthodontic brackets in vitro. American Journal of Orthodontics and Dentofacial Orthopedics 131 (6) 705e1-9; 2007. T R SUDJALIM, M WOODS, D MANTON, E REYNOLDS
- Synthesis and Characterisation of a Multiphosphorylated Phosphophoryn Repeat Motif; H-[Asp-(Ser(P))2]3-Asp-OH. International Journal of Peptide Research and Therapeutics 13 (4) 469-478; 2007. N O'BRIEN-SIMPSON, T ATTARD, A LOGANATHAN, N HUQ, K CROSS, P RILEY, E REYNOLDS
- Synthesis of Phosphopeptides in the Fmoc Mode. International Journal of Peptide Research and Therapeutics 13 (4) 447-468; 2007. T ATTARD, N O'BRIEN-SIMPSON, E REYNOLDS
- The Role of Multiphosphorylated Peptides in Mineralized Tissue Regeneration. International Journal of Peptide Research and Therapeutics 13, 497-495; 2007. K CROSS, N HUQ, N O'BRIEN-SIMPSON, J PERICH, T ATTARD, E REYNOLDS
- The role of multiphosphorylated peptides in mineralized tissue regeneration. International Journal of Peptide Research and Therapeutics 13 (4) 479-495; 2007. K CROSS, N HUQ, N O'BRIEN-SIMPSON, J PERICH, T ATTARD, E REYNOLDS
- The synthesis of phosphopeptides via the Bpoc-based approach. Organic & Biomolecular Chemistry 5 (4) 664-670; 2007. T ATTARD, E REYNOLDS, J PERICH
Publications in 2006
Book Chapters
- Anticariogenic Peptides. 2006 in Nutraceutical Proteins and Peptides in Health and Disease. CRC Press(Florida) Authors(s): K CROSS, N HUQ, E REYNOLDS Editors(s): Y Mine, F Shahidi
Journal Articles
- Role of oxyR in the oral anaerobe Porphyromonas gingivalis. Journal of Bacteriology 188 (7) 2454-2462; 2006. PI Diaz, N SLAKESKI, E REYNOLDS, R Morona, AH Rogers, PE Kolenbrander
- Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis. Microbiology 152 (Pt 8) 2381-2394; 2006. R PATHIRANA, N O'BRIEN-SIMPSON, P VEITH, P RILEY, E REYNOLDS
- Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate. Journal of Dairy Research 73 (1) 74-78 Author; 2006. G WALKER, F CAI, P SHEN, C REYNOLDS, B WARD, C FONE, S HONDA, M KOGANEI, M ODA, E REYNOLDS
- The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis. Journal of Bacteriology 188 (17) 6376-6386; 2006. C SEERS, N SLAKESKI, P VEITH, T NIKOLOF, Y CHEN, S DASHPER, E REYNOLDS
- Towards second-generation proteome analysis of murine enamel-forming cells. European Journal of Oral Sciences 114 (Suppl 1) 259-265; 2006. J MANGUM, P VEITH, E REYNOLDS, M HUBBARD
- Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection. Vaccine 24 (42-43) 6542-6554; 2006. L FRAZER, N O'BRIEN-SIMPSON, N SLAKESKI, K WALSH, P VEITH, CG Chen, IG Barr, E REYNOLDS
Publications in 2005
Journal Articles
- Divalent Metal Cations Increase the activity of the Antimicrobial Peptide Kappacin. Antimicrobial Agents and Chemotherapy 49 (6) 2322-2328; 2005. S DASHPER, N O'BRIEN-SIMPSON, K CROSS, R PAOLINI, B HOFFMANN, D CATMULL, M Malkoski, E REYNOLDS
- A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation. Journal of Biological Chemistry 280 (30) 28095-28102; 2005. S G DASHPER, C BUTLER, J P LISSEL, R A PAOLINI, B HOFFMANN, P D VEITH, N M O'BRIEN-SIMPSON, S L SNELGROVE, JT TSIROS, E C REYNOLDS
- A central role for the Hsp90-Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. Journal of Biological Chemistry 280, 9813-9822; 2005. D F DE NARDO, P J MASENDYCZ, S HO, M CROSS, A J FLEETWOOD, E C REYNOLDS, J A HAMILTON, G M SCHOLZ
- A prospective clinical study of bone augmentation techniques at immediate implants. Clinical Oral Implants Research 16 (2) 176-184; 2005. S T H CHEN, I B DARBY, G G ADAMS, E C REYNOLDS
- A proteomics strategy for the enrichment of receptor-associated complexes. Proteomics 5, 4754-4763; 2005. M CROSS, T NGUYEN, V BOGDANOSKA, E C REYNOLDS, J A HAMILTON
- A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4. Archives of Oral Biology 50 (7) 599-609; 2005. N L HUQ, K J CROSS, M UNG, E C REYNOLDS
- Adding casein phosphopeptide-amorphous calcium phosphate to sports drinks to eliminate in vitro erosion. Pediatric Dentistry 27 (1) 61-67; 2005. L RAMALINGAM, L J BREARLEY MESSER, E C REYNOLDS
- An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects Against Porphyromonas gingivalis-Induced Periodontal Bone Loss. Journal of Immunology 175 (6) 3980-3989; 2005. N M O'BRIEN-SIMPSON, R D PATHIRANA, R A PAOLINI, Y Y CHEN, P D VEITH, V TAM, N ALLY, RN PIKE, E C REYNOLDS
- Association of bovine dentine phosphophoryn with collagen fragments. Archives of Oral Biology 50 (9) 807-819; 2005. N L HUQ, A LOGANATHAN, K J CROSS, Y Y CHEN, NI JOHNSON, M WILLETTS, P D VEITH, E C REYNOLDS
- Combating dental decay. Microbiology Australia 26 (3) 107-109; 2005. S G DASHPER, E C REYNOLDS
- Divalent Metal Cations Increase the Activity of the Antimicrobial Peptide Kappacin. Antimicrobial Agents and Chemotherapy 49 (6) 2322-2328; 2005. S G DASHPER, N M O'BRIEN-SIMPSON, K J CROSS, R A PAOLINI, B HOFFMANN, D V CATMULL, M MALKOSKI, E C REYNOLDS
- Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis. Journal of Biological Chemistry 280 (10) 8668-8677; 2005. K SATO, E SAKAI, P D VEITH, M SHOJI, Y KIKUCHI, H YUKITAKE, N OHARA, M NAITO, K OKAMOTO, E C REYNOLDS, K NAKAYAMA
- Physicochemical Characterization of Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes. Journal of Biological Chemistry 280 (15) 15362-15369; 2005. K J CROSS, N L HUQ, J PALAMARA, J W PERICH, E C REYNOLDS
- Protein dynamics of bovine dentin phosphophoryn. Journal of Peptide Research 66 (2) 59-67; 2005. K J CROSS, N L HUQ, E C REYNOLDS
- S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research 4 (1) 136-145; 2005. S BOZINOVSKI, M CROSS, R VLAHOS, J E JONES, K HSUU, E C REYNOLDS, D HUME, J A HAMILTON, PA TESSIER, CL GECZY, G P ANDERSON
Conference Publications/Papers
- New modalities for a new generation: Casein phosphopeptide-amorphous calcium phosphate, a new remineralization technology. 2005. 14th ANZSPD Biennial Conference. Synopses March 2005: 30, 1 - 6. Publisher: Australian and New Zealand Society for Paediatric Dentistry(Melbourne). E C REYNOLDS
Publications in 2004
Journal Articles
- Porphyromonas gingivalis RgpA and Kgp proteinases and adhesins are C Terminally processed by the carboxypeptidase CPG70. Infection and Immunity 72 (6) 3655-3657; 2004. P D VEITH, Y Y CHEN, E C REYNOLDS
- Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. Caries Research 38 (6) 551-556; 2004. Y IIJIMA, F CAI, P SHEN, G D WALKER, C REYNOLDS, E C REYNOLDS
- Antigens of bacteria associated with periodontitis. Periodontology 2000 35, 101-134; 2004. N M O'BRIEN-SIMPSON, P D VEITH, S G DASHPER, E C REYNOLDS
- Characterization of two outer membrane protein antigens of Porphyromonas gingivalis that are protective in a murine lesion model. Oral Microbiology and Immunology 19 (1) 6-15; 2004. B ROSS, L CRAJKOWSKI, KL VANDENBERG, S CAMUGLIA, J WOODS, C AGIUS, R A PAOLINI, E C REYNOLDS, IG BARR
- Hemoglobin hydrolysis and heme acquisition by Porphyromonas gingivalis. Oral Microbiology and Immunology 19 (1) 50-56; 2004. S G DASHPER, K J CROSS, N SLAKESKI, J P LISSEL, P AULAKH, C MOORE, E C REYNOLDS
- Molecular modelling of the multiphosphorylated casein phosphopeptide αS1-casein(59-79) based on NMR constraints. Journal of Dairy Research 71 (1) 28-32; 2004. N L HUQ, K J CROSS, E C REYNOLDS
- NMR studies of a novel calcium, phosphate and fluoride delivery vehicle-αS1-casein(59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes. Biomaterials 25 (20) 5061-5069; 2004. K J CROSS, N L HUQ, D P STANTON, M M SUM, E C REYNOLDS
- Production of a high gel strength whey protein concentrate from cheese whey. Journal of Dairy Science 87 (4) 831-840; 2004. P D VEITH, E C REYNOLDS
- Whole and parotid saliva - protein profiles as separated on 5-20% SDS-polyacrylamide gradient gel electro-phoresis and using maldi-tof mass spectrometry. Annals of Dentistry 11 (1) 24-29; 2004. N HUQ, A DeAngelis, ZHA Rahim, M UNG, J Lucas, K CROSS, E REYNOLDS
CURRENT GRANTS (Last 5 years)
| Title | Role | Funding Source | Scheme | Award Date |
|---|---|---|---|---|
| Identification of Porphyromonas gingivalis genes required for iron/heam acquisition and biofilm formation | Chief Investigator | NHMRC | Project Grants | 01/01/2004 |
| Biomarkers in gingival crevicular fluid: A mass sp | Principal Supervisor | NHMRC | Medical & Dental Postgraduate Scholarships | 01/01/2004 |
| An electoporation system: BTX ECM 2001 embryo manipulation system | Chief Investigator | RAMACIOTTI FOUNDATION | Major Equipment Grant | 01/01/2005 |
| Molecular characterization of the gingipains of Porphyromonas gingivalis | Chief Investigator | NHMRC | Project Grants | 01/01/2005 |
| Remineralisation of mineral deficient enamel using CPP-ACFP | Principal Supervisor | NHMRC | Dora Lush Biomedical Postgraduate Scholarship | 01/01/2005 |
| AN INVESTIGATION INTO THE EFFECT OF OXIDATIVE ENAMEL PRE-CONDITIONING ON THE REMINERALIZATION OF NATURAL WHITE SPOT LESIONS OF DENTAL ENAMEL WITH CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE (CPP-ACP) | Chief Investigator | AUST DENTAL RESEARCH FOUNDATION | Research Grant | 01/01/2006 |
| Polymicrobial interactions in a biofilm of periodontopathic bacteria | Chief Investigator | NHMRC | Project Grants | 01/01/2006 |
| Characterization of casein phosphopeptide amorphous calcium fluoride phosphate as a remineralization system | Chief Investigator | NHMRC | Project Grants | 01/01/2006 |
| Development of a synthetic peptide vaccine | Chief Investigator | NHMRC | Project Grants | 01/01/2007 |
| Genetic studies of an oral bacterial pathogen | Chief Investigator | NHMRC | Project Grants | 01/01/2007 |
| Characterization of a novel bacterial secretion system. | Chief Investigator | NHMRC | Project Grants | 01/01/2008 |
| Development of a vaccine to Porphyromonas gingivalis | Chief Investigator | NHMRC | Project Grants | 01/01/2009 |
| Characterisation and remineralisation of natural white spot lesions by X-ray microtomography (micro-CT) and Synchrotron X-ray microtomography (synchrotron-CT) analysis | Chief Investigator | AUST DENTAL RESEARCH FOUNDATION | RW Hession Award | 01/01/2009 |
| MELBOURNE BIOMOLECULAR NMR NETWORK | Chief Investigator | MONASH UNIVERSITY, UNIVERSITY OF MELBOURNE |
Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) | 01/01/2009 |
| Enhanced enamel remineralisation | Chief Investigator | NHMRC | Project Grants | 01/01/2009 |