Dr Laila Huq
CONTACT DETAILS
Dr. Laila Huq
BSc Hons Coordinator
Education Program Leader Oral Health CRC
Bio21 30 Flemington Rd
The University of Melbourne
Victoria 3010 Australia
E-mail: laila@unimelb.edu.au
Telephone: +61 3 8344 2574
QUALIFICATIONS AND POSITIONS
- 1979-1982 B.Sc., University of Auckland.
- 1982-1984 M.Sc., Hons. 1st class, University of Auckland.
- 1984-1988 Ph.D., University of New South Wales.
- B.Sc. Honours Coordinator.
- Education Program Leader Oral Health CRC.
CURRENT RESEARCH INTERESTS
(Projects that are available for BSc Honours, MSC, and PhD students are indicated by an asterisk*)
- Nanotechnology: Structure-Function Studies of Casein Phosphopeptides.*
- Structure-function studies and biomimetics of phosphorylated peptides and proteins.*
- Structure-function studies of salivary proteins.*
- Salivary Informatics.*
- Identification of bioactive peptides from milk.*
- Evolutionary Bioinformatics of Cysteine Protease and Protease Inhibitors.
PhD projects available at Melbourne Dental School
Natural inhibitors of bacterial pathogen proteases
This is an opportunity for highly motivated and enthusiastic students to undertake a multidisciplinary research project that has commerciallization potential.
Contact Dr Laila Huq email: laila@unimelb.edu.au
Australians and NZ citizens
- There are no tuition fees.
- You will be assessed on your academic abilities to undertake a research project.
- If you have an Australian Postgraduate Scholarship or equivalent, you may also apply for an Oral Health CRC top-up scholarship.
International Students
- There are no tuition fees, if you have a guaranteed scholarship from your country that covers your living expenses.
- You may eligible for a highly competitive Melbourne International Research scholarship
- If you do not hold a scholarship you will need to pay tuition fees of approx $32,000 every year
CURRENT PUBLICATIONS
BOOKS
- Cross KJ, Huq NL, Reynolds EC, (2006) Anticariogenic Peptides. In: Nutraceutical Proteins and Peptides in Health and Disease. Boca Raton: Taylor and Francis.
JOURNALS
- Huq, N.L., Cross, K.J., Reynolds, E.C. (2000) Molecular Modelling Of A Multi-Phosphorylated Sequence Motif Bound To Hydroxyapatite Surfaces. J. Mol. Mod., 6, 35-47.
- Huq, N.L., Cross, K.J., Talbo, G.H., Riley, P.F., Loganathan, A., Crossley, M.A., Perich, J.W., And Reynolds, E.C. (2000) N-terminal Sequence Analysis of Bovine Dentine Phosphophoryn After Conversion of Phosphoseryl To S-Propylcysteinyl Residues. J. Dent. Res. 79: 1914-1919.
- Cross KJ, Huq NL, Bicknell W, Reynolds EC. (2001) Cation–Dependent Structural Features of β-casein(1-25). Biochem. J. 356, 277-285.
- Huq, N.L., Cross, K.J., And Reynolds E.C. (2003) Nascent Helix In The Multiphosphorylated Peptide αS1-Casein(2-20). J. Peptide Sci. 9(6), 386-392
- Huq, N.L., Cross, K.J., And Reynolds E.C. (2004) Molecular Modeling of The Multiphosphorylated Anticariogenic Casein Phosphopeptide aS1-Casein(59-79) Based on NMR Constraints. J Dairy Sci. 71, 1-5.
- Cross, K.J., Huq, N.L., Stanton, D., Sum, M., And Reynolds, E.C. (2004) NMR Spectroscopy and Mass Spectroscopic Studies of A Novel Calcium, Phosphate and Fluoride Delivery Vehicle-The Multiphosphorylated Peptide aS1-Casein(59-79) Complexed With Amorphous Calcium Fluoride Phosphate. Biomaterials 25, 20, 5061-5069.
- Huq, N.L., K.J. Cross, M. Ung & E. C. Reynolds (2005). A review of protein structure and gene organization for proteins associated with mineralised tissue and calcium phosphate stabilization encoded on human chromosome 4. Archives of Oral Biology 50, 599-609.
DOI:10.1016/j.archoralbio.2004.12.009(PDF 411kb) - Huq, N. L., A. Loganathan, K. J. Cross, N. I. Johnson, M. Willetts, Y. Chen, P. Veith And E. C. Reynolds (2004). Association of collagen fragments with bovine dentine phosphophoryn. Archives of Oral Biology 50, 807-819.
DOI:10.1016/j.archoralbio.2005.02.002 (PDF 313kb) - Cross, K.J., Huq, N.L., Palamara, J., Perich, J.W. And Reynolds, E.C. (2005) Physicochemical Characterization of Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes. (2005) J. Biol. Chem. 280 (15): 15362-15369
- Cross, K.J., Huq, N.L., And Reynolds, E.C. Protein Dynamics of Bovine Phosphophoryn. (2005) J. Pept. Res. 66(2):59-67
- Cross KJ, Huq NL, Reynolds EC. (2007) Casein Phosphopeptides in Oral Health - Chemistry and Clinical Applications. Theme: Food-derived bioactive proteins and peptides as potential components of nutraceuticals. Current Pharmaceutical Design 2007
- Cross, K.J., Huq, N.L., O’Brien-Simpson, N.M., Perich, J.W., Attard, T.J., Reynolds (2007) The Role of Multiphosphorylated Peptides in Mineralized Tissue Regeneration Journal of Peptide Research and Therapeutics 13(4) 479-495.
- O’Brien-Simpson, N.M., Attard, TJ., Loganathan, A., Huq, N.L., Cross, K.J., Riley, P.F. & Reynolds, E.C. (2007) Synthesis and Characterisation of a Multi-phosphorylated Phosphophoryn repeat motif: H-[Asp-(Ser(P))2]3-Asp-COOH. Journal of Peptide Research and Therapeutics. 13(4) 469-478.
- Huq, N.L., Cross, K.J., Ung, M., Myroforidis, H., Veith, P., Chen, D., Stanton, D.P., He, H., Ward, B., and Reynolds, E.C. (2007) A Review of the Salivary Proteome and Peptidome and Saliva-derived Peptide Therapeutics. Journal of Peptide Research and Therapeutics. 13(4) 547-564.
- Kitasako, Y. Burrow, M.F., Stacey, M., Huq, N.L. Reynolds, E.C. and Tagami J (2008) “Comparative analysis of three commercial saliva testing kits with a standard saliva buffering test” Australian Dental Journal 53 (2) 142-144.
- Kitasako, Y. Burrow, M.F., Huq, N.L. Stacey, M., Reynolds, E.C. and Tagami J (2009) “A simplified quantitative test for resting saliva buffering capacity compared to a standard test- adapted Checkbuf test.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 108:551-556
- Toh, E.C.Y., Huq, N.L. Dashper, Reynolds, E.C. (2010) “Cysteine Protease Inhibitors: From evolutionary relationships to modern chemotherapeutic design” Current Protein and Peptide Science. Accepted for publication
- Cochrane, N.J., Cai, F., Huq, N.L. Burrow, M.F. & Reynolds E.C. (2010) “New Approaches to Enhance Remineralization of Tooth Enamel” accepted for publication Critical Reviews in Oral Biology. Aug 25. [Epub ahead of print]
MEMBERSHIPS
- Mineralized Tissue, International Association for Dental Research.
- Australasian Proteomics Society
TEACHING INTERESTS
- Undergraduate: Biomineralisation of Dentine and Enamel, Salivary Proteins
- Postgraduate Common Core: Bioinformatics and Cheminformatic