Dr Laila Huq
CONTACT
E-mail: laila@unimelb.edu.au
Telephone: +61 3 8344 2574
QUALIFICATIONS AND POSITIONS
- 1979-1982 B.Sc., University of Auckland.
- 1982-1984 M.Sc., Hons. 1st class, University of Auckland.
- 1984-1988 Ph.D., University of New South Wales.
- CRC for Oral Health Science: Graduate Studies Coordinator.
- B.Sc. Honours Coordinator.
CURRENT RESEARCH INTERESTS
(Projects that are available for BSc Honours, MSC, and PhD students are indicated by an asterisk*)
- Nanotechnology: Structure-Function Studies of Casein Phosphopeptides*
- Structure-function studies and biomimetics of phosphorylated peptides and proteins.*
- Structure-function studies of salivary proteins*
- Salivary Informatics*
- Identification of bioactive peptides from milk
- Bioinformatics of oral, craniofacial and dental disorders.
- Genetics of Dentinogenesis imperfecta and Osteogenesis imperfecta.
CURRENT PUBLICATIONS
BOOKS
- Cross KJ, Huq NL, Reynolds EC, Anticariogenic Peptides. In: Nutraceutical Proteins and Peptides in Health and Disease. Boca Raton: Taylor and Francis; 2006
JOURNALS
- HUQ, N.L., CROSS, K.J., REYNOLDS, E.C. (2000) Molecular Modelling of a Multi-phosphorylated Sequence Motif Bound to Hydroxyapatite Surfaces. J. Mol. Mod., 6, 35-47.
- HUQ, N.L., CROSS, K.J., TALBO, G.H., RILEY, P.F., LOGANATHAN, A., CROSSLEY, M.A., PERICH, J.W., and REYNOLDS, E.C. (2000) N-terminal Sequence Analysis of Bovine Dentine Phosphophoryn After Conversion of Phosphoseryl to S-propylcysteinyl Residues. J. Dent. Res. 79: 1914-1919.
- CROSS KJ, HUQ NL, BICKNELL W, REYNOLDS EC. (2001) Cation–dependent structural features of β-casein(1-25). Biochem. J. 356, 277-285.
- HUQ, N.L., CROSS, K.J., and REYNOLDS E.C. (2003) Nascent Helix in the Multiphosphorylated Peptide αS1-Casein(2-20). J. Peptide Sci. 9(6), 386-392
- HUQ, N.L., CROSS, K.J., and REYNOLDS E.C. (2004) Molecular modeling of the multiphosphorylated anticariogenic casein phosphopeptide αS1 Casein(59-79) based on NMR constraints. J Dairy Sci. 71, 1-5.
- CROSS, K.J., HUQ, N.L., STANTON, D., SUM, M., AND REYNOLDS, E.C. (2004) NMR Spectroscopy and mass spectroscopic studies of a novel calcium, phosphate and fluoride delivery vehicle-the multiphosphorylated peptide αS2-Casein(59-79) complexed with amorphous calcium fluoride phosphate. Biomaterials 25, 20, 5061-5069.
- HUQ, N. L., K. J. CROSS, M. UNG AND E. C. REYNOLDS (2005). A review of protein structure and gene organization for proteins associated with mineralised tissue and calcium phosphate stabilization encoded on human chromosome 4. Archives of Oral Biology 50, 599-609.
DOI:10.1016/j.archoralbio.2004.12.009 (PDF 411kb) - HUQ, N. L., A. LOGANATHAN, K. J. CROSS, N. I. JOHNSON, M. WILLETTS, Y. CHEN, P. VEITH AND E. C. REYNOLDS (2004). Association of collagen fragments with bovine dentine phosphophoryn. Archives of Oral Biology 50, 807-819.
DOI:10.1016/j.archoralbio.2005.02.002 (PDF 313kb) - CROSS, K.J., HUQ, N.L., PALAMARA, J., PERICH, J.W. and REYNOLDS, E.C. Physicochemical Characterization of Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes. (2005) J. Biol. Chem. 280 (15): 15362-15369
- CROSS, K.J., HUQ, N.L., and REYNOLDS, E.C. Protein Dynamics of Bovine Phosphophoryn. (2005) J. Pept. Res. 66(2):59-67
- Cross KJ, Huq NL, Reynolds EC. Casein Phosphopeptides in Oral Health - Chemistry and Clinical Applications. Theme: Food-derived bioactive proteins and peptides as potential components of nutraceuticals. Current Pharmaceutical Design In press 2007
MEMBERSHIPS
- Mineralized Tissue, International Association for Dental Research.
- Australasian Proteomics Society
TEACHING INTERESTS
- Undergraduate: Biomineralisation of Dentine and Enamel, Salivary Proteins
- Postgraduate Common Core: Bioinformatics and Cheminformatic